V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity

Summary: Antibodies that bind residue K169 in the V2 region of the HIV-1 envelope correlated with reduced risk of infection in the RV144 vaccine trial but were restricted to two ED-motif-encoding light chain genes.Here, we identify an HIV-infected donor with high-titer V2 peptide-binding antibodies and isolate two antibody lineages (CAP228-16H/19F

read more

Plant tissue culture challenges in Ethiopia and alternative options for low-cost media [version 1; peer review: 1 approved, 2 approved with reservations]

Plant tissue culture (PTC) is the cultivation of any part of a plant in nutritionally defined media under an aseptic and controlled environment, regardless of season and weather.The application of PTC leads to the mass propagation of varietal, high-quality Cases seedlings of ornamental plants, medicinal plants, plantation crops, fruit trees, and fo

read more